Methamphetamine, commonly referred to as meth, speed, or crack, is a powerful stimulant drug that affects the central nervous system. While some drugs slow down the body, meth speeds it up by triggering a burst of energy and an intense rush of euphoria. It also boosts alertness, reduces appetite, increases activity and talkativeness, and offers a general sense of happiness and well-being. Methamphetamine dependence is a growing problem in various areas of the world. The development of effective treatments for methamphetamine dependence has become a pressing concern. Recent improvements in the understanding of the underlying neurobiology of methamphetamine dependence have led to a number of potentially useful pharmacological agents.

How to Choose the Right Treatment Program

Currently, there is no pharmacological therapy with established efficacy for the treatment of this addictive disorder, nor is there any medication approved by the regulatory authorities for such treatment 30. The need to find effective treatments for methamphetamine dependence has been identified as a priority by the United States National Institute on Drug Abuse (NIDA) and by European investigators. Various neuronal mechanisms implicated in methamphetamine dependence have suggested several pharmacological approaches. Recent reviews on pharmacotherapy for methamphetamine dependence have been published 30–34, but this is a quickly evolving area with preclinical findings and clinical alcoholism treatment trials reported frequently. Although there is not much substantial evidence in terms of proof of concept studies and randomized clinical trials, this review will bring to light some of the newer pharmacological targets.

meth dependence

Is Binge Drinking Alcoholism? Understanding the Distinctions and Risks

Modafinil may be a cognitive enhancer 50 in methamphetamine-dependent patients 51 and may therefore have the potential to improve the response to behavioural therapies. Because of its weak stimulant properties, modafinil has been cited as a putative treatment to decrease stimulant drug seeking and craving. Methamphetamine dependence is a serious worldwide public health problem with major medical, psychiatric, socioeconomic and legal consequences. A literature search from a range of electronic databases (PubMed, EMBASE, PsycInfo, the NIDA research monograph index and the reference list of clinicaltrials.gov) was conducted for the period from January 1985 to October 2009. There were no restrictions on the identification or inclusion of studies in terms of publication status, language and design type. A variety of medications have failed to show efficacy in clinical trials, including a dopamine partial agonist (aripiprazole), GABAergic agents (gabapentin) and serotonergic agents (SSRI, ondansetron, mirtazapine).

Methamphetamine: What you should know

This is why your loved one might seem confused, forgetful, or have trouble with tasks they normally do easily. These changes aren’t necessarily permanent, but they are sign that your loved one needs professional care. Meth is an extremely strong psychostimulant, which means it drastically affects sleep patterns.4 It’s known for causing days-long binges during which people stay awake for days on end. Meth causes severe tooth decay called “meth mouth.”2 You might notice your loved one covering their mouth when they smile, complaining of tooth pain, or having bad breath. Outpatient programs, on the other hand, allow individuals to live at home while attending scheduled therapy sessions and support groups, making them suitable for those with mild to moderate addiction or strong support systems.

Behavioral Changes

We will focus on agents affecting the biogenic amine transporters mentioned above and other neurotransmitter systems (acetylcholine, GABA, endogenous opioids, endocannabinoids). We will also discuss pharmacological candidates in the pipeline such as immunotherapies (vaccine, anti-methamphetamine monoclonal antibodies) and other approaches based on preclinical data. We will not discuss the management of acute methamphetamine intoxication or the treatment of methamphetamine dependence in patients with comorbid psychiatric disorders.

What are the Complications of Meth Addiction?

Counseling and therapy are integral components of treating meth addiction. Cognitive-behavioral therapy (CBT) is one of the most commonly used therapies in addiction treatment. CBT equips individuals with essential skills to overcome substance use challenges, including meth dependence understanding substance abuse, developing coping skills, and avoiding relapse. This process involves flushing the drug out of the individual’s system under medical supervision. Detoxification is a challenging process due to the physical and psychological withdrawal symptoms that occur.

meth dependence

Physical and Psychological Effects of Meth Addiction

Methamphetamine overdose is a toxic, potentially life threatening reaction to the drug. Your risk of overdose increases if you take a large https://www.eng.rmuti.ac.th/stiswb2024/?p=2926 dose of meth or mix methamphetamine with other drugs. It may take some time for your brain to restore its dopamine circuits when you stop using meth. So, the cognitive abilities that don’t rely much on dopamine will likely recover first. Mental health symptoms like paranoia and delusions may take longer to disappear.

Dependence refers to a physical state in which your body is dependent on the drug. With drug dependence, you need more and more of the substance to achieve the same effect (tolerance). You experience mental and physical effects (withdrawal) if you stop taking the drug. From intensive behavioral therapies to supportive group sessions, we offer a range of services designed to address the physical, psychological, and emotional aspects of addiction.

The APA replaced “dependence” and “abuse” with “substance use disorder” in the 2013 edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). This diagnosis focuses on the disorder involving the use of the substance. The American Psychiatric Association (APA) used to distinguish between dependence and abuse. Abuse was considered the mild or early phase of inappropriate drug use that led to dependence. These numbers show the urgent need for awareness and targeted interventions to address polysubstance abuse involving these hazardous drugs.

Toward a Comprehensive Solution in Addressing the Methamphetamine Crisis

Meth addiction can be harmful to health, to the extent that it can even be fatal. It’s important to recognize this addiction and seek help for it as soon as possible. Behavioral therapies have proven effective in treating meth addiction and can help you live a substance-free life.

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